Table 2.
mAbs that target the components of bone marrow microenvironment.
| Target | Antibody | Phase | Status | Identifier |
|---|---|---|---|---|
| IL-6 | Siltuximab | II | C | NCT00911859 |
| VEGF | Bevacizumab | II | C | N01-CM-62209 |
| BAFF | LY2127399 | I | C | - |
| RANKL | Denosumab | III | C | NCT00330759 |
| DKK1 | BHQ880 | I | C | NCT20050244 |
| IL-6 | Siltuximab | II | C | NCT00911859 |
R: Recruiting; C: Completed; ONR: Ongoing, not recruiting; BAFF: B-cell activating factor;