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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Neurochem. 2016 Oct 18;139(4):576–585. doi: 10.1111/jnc.13769

Figure 2. Acute lithium treatment does not change stimulation-evoked, extracellular DA levels.

Figure 2

(A) Stimulation-evoked extracellular DA concentration from representative mice that were acutely treated 5 hours earlier with lithium chloride (300 mg/kg) or vehicle. Voltammetric recordings began 5 seconds prior to electrical stimulation. Arrows at t=0 indicate the onset of VTA stimulation. Each electrical stimulation consisted of 60 pulses, 1 sec. in duration, with varying levels of pulse amplitude (100–500 µA). Inset: Color plots showing DA signals represented by the signal in the approximate center (~0.6 V) of the rising phase of the voltage ramp, from representative mice stimulated at 300 µA pulse amplitude. X-Axis: Time (seconds), Y-Axis: Applied potential, Z-Axis (in pseudocolor): DA concentration levels. Group averages of the (B) amplitude, (C) rise time and (D) decay constants of evoked DA levels. Acute treatment with lithium chloride does not affect the magnitude of ([DA]max), rise time of DA concentrations, or decay time constants. For panels B–D, error bars indicate mean ± SEM. n=12/group.