Table 3.
The βDX ± standard errors are shown, following multiplication by (−1 × 102) factor, with the corresponding P‐values for the whole‐brain and regional analysis of impact of diagnosis on white matter FA values
| Cohort A | Cohort B | Cohort C | Mega | Meta | |
|---|---|---|---|---|---|
| Average | 1.21 ± 0.21 ( P = 3.0E‐08) | 0.91 ± 0.31 ( P = 4E‐03) | 0.85 ± 0.35 ( P = 6E‐03) | 1.1 ± 0.1 ( P = 1E‐11) | P = 2E‐10 |
| Genu of Corpus Callosum (GCC) | 2.8 ± 0.50 ( P = 1.0E‐07) | 2.74 ± 0.91 (P = 8E‐03) | 2.2 ± 0.88 ( P = 3E‐03) | 2.5 ± 0.4 ( P = 1E‐10) | P = 8E‐10 |
| Body of Corpus Callosum (BCC) | 3.81 ± 0.71 ( P = 1E‐07) | 2.5 ± 0.80 (P = 0.06) | 1.6 ± 1.2 (P = 4E‐03) | 2.4 ± 0.5 ( P = 8.0E‐08) | P = 1E‐07 |
| Splenium of Corpus Callosum (SCC) | 2.24 ± 0.40 ( P = 9E‐08) | 1.02 ± 1.05 (P = 0.3) | 0.65 ± 0.8 (P = 0.15) | 1.50 ± 0.3 ( P = 4E‐06) | P = 7E‐05 |
| Cingulum (Cing) | 1.50 ± 0.43 ( P = 4E‐05) | 0.50 ± 0.70 (P = 0.2) | 1.45 ± 0.81 (P = 0.1) | 1.2 ± 0.3 ( P = 1E‐05) | P = 8E‐05 |
| Corona Radiata (CR) | 1.70 ± 0.40 ( P = 9E‐11) | 1.4 ± 0.7 (P = 0.01) | 0.45 ± 0.30 (P = 0.03) | 1.5 ± 0.2 ( P = 3E‐11) | P = 3E‐10 |
| Internal Capsule (IC) | 2.51 ± 0.43 ( P = 2E‐09) | 1.94 ± 0.68 (P = 0.04) | 1.2 ± 0.50 ( P = 2E‐03) | 0.9 ± 0.2 ( P = 1E‐5) | P = 2.0E‐5 |
| External Capsule (EC) | 1.50 ± 0.35 ( P = 1E‐06) | 1.41 ± 0.44 (P = 0.05) | 0.90 ± 0.45 ( P = 2.5E‐03) | 1.2 ± 0.2 ( P = 2E‐9) | P = 2E‐08 |
| Superior Frontal‐Occipital (SFO) | 2.2 ± 0.45 ( P = 3E‐07) | 1.8 ± 0.65 ( P = 3E‐04) | 2.40 ± 0.60 (P = 0.01) | 2.0 ± 0.3 ( P = 8E‐11) | P = 1E‐9 |
| Inferior Frontal Occipital (IFO) | 1.51 ± 0.51 ( P = 4E‐03) | 0.21 ± 0.81 (P = 0.15) | 1.00 ± 0.75 (P = 0.5) | 1.0 ± 0.40 ( P = 3E‐03) | P = 0.008 |
| Posterior Thalamic Radiation (PTR) | 1.48 ± 0.45 ( P = 2.5E‐04) | 0.5 ± 0.60 (P = 0.07) | 2.2 ± 0.87 (P = 0.1) | 1.1 ± 0.2 ( P = 1E‐05) | P = 7E‐05 |
| Sagittal Stratum (SS) | 2.1 ± 0.39 ( P = 6E‐08) | 1.62 ± 0.65 (P = 0.04) | 1.3 ± 0.57 (P = 0.01) | 1.7 ± 0.3 ( P = 4E‐10) | P = 1E‐9 |
| Superior Longitudinal Fasciculus (SLF) | 1.45 ± 0.35 ( P = 3E‐05) | 1.35 ± 0.50 (P = 0.05) | 1.40 ± 0.6 (P = 0.01) | 1.1 ± 0.2 ( P = 7E‐07) | P = 1E‐06 |
The β DX values indicate (Control – Patient)/100 difference, in FA values. Bolded values are significant after correcting for multiple (N = 12) comparisons. Nominally significant values are shown in italic.