Table 4.
The β Age×DX ± standard error (P‐values) are shown, after multiplication by −104 scaling factor, for whole‐brain and regional analysis of accelerated (FA units/year) decline with in patients (DX = 1)
| Cohort A | Cohort B | Cohort C | Mega | Meta | |
|---|---|---|---|---|---|
| Average | 1.60 ± 0.8 ( P = 0.04) | 1.23 ± 1.40 (P = 0.3) | 1.45 ± 1.15 ( P = 0.04) | 1.22 ± 0.63 ( P = 0.02) | P = 0.04 |
| Genu of Corpus Callosum (GCC) | 5.4 ± 1.9 ( P = 4.0E‐03) | 7.2 ± 3.8 (P = 0.05) | 4.10 ± 3.5 (P = 0.09) | 4.4 ± 1.5 ( P = 0.004) | P = 0.01 |
| Body of Corpus Callosum (BCC) | 12.3 ± 2.5 ( P = 5.0E‐05) | 8.4 ± 3.6 (P = 0.01) | 0.5 ± 3.9 (P = 0.5) | 5.0 ± 2.0 (P = 1.0E‐04) | P = 1E‐03 |
| Splenium of Corpus Callosum (SCC) | 3.38 ± 1.5 (P = 0.01) | 7.6 ± 4.0 (P = 0.03) | 4.93 ± 2.97 (P = 0.05) | 2.9 ± 1.3 (P = 0.01) | P = 0.03 |
| Cingulum (Cing) | 3.6 ± 1.7 ( P = 1E‐03) | 5.1 ± 2.6 ( P = 1E‐03) | −0.19 ± 2.61 (P = 0.5) | 2.7 ± 1.25 (P = 0.02) | P = 0.02 |
| Corona Radiata (CR) | 3.8 ± 1.2 ( P = 1E‐03) | 2.1 ± 1.5 (P = 0.01) | 3.20 ± 1.96 (P = 0.04) | 2.7 ± 0.92 ( P = 1.0E‐03) | P = 2.0E‐03 |
| Internal Capsule (IC) | 3.3 ± 1.20 (P = 8.0E‐03) | 3.5 ± 2.1 (P = 0.07) | 1.12 ± 1.67 (P = 0.3) | 0.4 ± 0.9 (P = 0.4) | P = 0.05 |
| External Capsule (EC) | 2.5 ± 1.1 ( P = 1E‐03) | 1.2 ± 1.8 (P = 0.28) | 0.21 ± 1.73 (P = 0.45) | 1.6 ± 0.81 (P = 0.04) | P = 0.07 |
| Superior Frontal‐Occipital (SFO) | 2.1 ± 1.2 (P = 0.01) | 2.6 ± 2.6 (P = 0.2) | 2.06 ± 2.51 (P = 0.21) | 2.9 ± 1.2 (P = 0.01 ) | P = 0.02 |
| Inferior Frontal Occipital (IFO) | 5.1 ± 2.3 ( P = 1.3E‐03) | −3.0 ± 3.5 (P = 0.8) | 0.60 ± 3.12 (P = 0.42) | 1.9 ± 1.6(P = 0.1) | P = 0.2 |
| Posterior Thalamic Radiation (PTR) | 0.4 ± 1.2 (P = 0.4) | 1.1 ± 2.4 (P = 0.3) | 7.43 ± 3.30 (P = 0.01) | 0.9 ± 1.37 (P = 0.2) | P = 0.2 |
| Sagittal Stratum (SS) | 1.07 ± 1.5 (P = 0.4) | 1.7 ± 2.5 (P = 0.2) | 5.03 ± 2.11 (P = 0.01) | 1.8 ± 1.1 (P = 0.05) | P = 0.1 |
| Superior Longitudinal Fasciculus (SLF) | 1.2 ± 1.3 (P = 0.3) | 0.6 ± 1.8 (P = 0.6) | 3.99 ± 1.97 (P = 0.02) | 1.2 ± 0.89 (P = 0.1) | P = 0.15 |
Higher, positive βAge×DX values indicate greater decline with age. Bolded values are significant after correcting for multiple (N = 12) comparisons. Nominally significant values are shown in italic.