Table 2.
LD50 values for mouse infection with G9241 or isogenic atxA mutants
| A/J mice | C57BL/6 mice | |||
|---|---|---|---|---|
| Strain | s.c. LD50 | i.n. LD50 | s.c. LD50 | i.n. LD50 |
| G9241 | 7 a | 3 × 103 a | 44 a
(16 – 100) |
4 × 105
a
(2 × 105 – 9 × 105) |
| Δ atxA1 | 24 a
(7 – 36) |
8 × 103 a | 800 a, c
(200 – 3 × 103) |
8 × 106 b |
| Δ atxA2 | <20 | 3 × 103
a
(1 × 103 – 6 × 103) |
300 a, c
(100-900) |
2 × 106
a
(7 × 105 – 9 × 107) |
| Δ atxA1 Δ atxA2 | >107 | >107 | - | - |
a
LD50 calculated by probit analysis with 95% confidence interval, if given by SPSS software, in parentheses
b
LD50 calculated with Reed and Muench method as criteria for probit analysis were not met (Reed & Muench, 1938)
c
Significantly different from G9241 LD50 as determined by comparison of relative median potencies (P < 0.05)