Table 2.

Age- and Multivariable-Adjusted Relative Risks for Incident Vertebral Fracture According to Diuretic Use^*

	Thiazide Use
	No	Yes
Cases of Vertebral Fracture (n)	316	104
Person-years (n)	451,178	92,032
Age-adjusted Relative Risk (95% CI)	1.0	1.44 (1.16, 1.80)
Multivariate Relative Risk (95% CI) †	1.0	1.47 (1.18, 1.85)
	Furosemide Use
	No	Yes
Cases of Vertebral Fracture (n)	382	38
Person-years (n)	521,248	21,961
Age-adjusted Relative Risk (95% CI)	1.0	1.63 (1.16, 2.28)
Multivariate Relative Risk (95% CI) †	1.0	1.59 (1.12, 2.25)

^*Thiazide and furosemide use were updated throughout the analysis period (2002–2012). Relative risks are for the risk of vertebral fracture compared with the group that did not use diuretics.

^†The multivariate model includes: body mass index, race, physical activity, history of falls, smoking status, alcohol intake, supplemental calcium intake, quintiles of diet calcium intake, total vitamin D intake, vitamin A intake, total protein intake, self-reported diabetes or osteoporosis, history of beta-blocker use, bisphosphonate use, oral steroid use, or postmenopausal hormone use, and recent physical exam.