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(A) Four possible binding modes of ARID domain onto 5FWJ structure after applying constraint of linker length. (B) RMSD of ARID domain and JmjC domain. (C) RMSD of the interfacial residues. (D) Finalized model of ARID bound to KDM5C catalytic core including JmjN, ARID, JmjC, ZF domains and the rest of inter domain regions marked with yellow, green, purple, orange and blue, respectively.
