Finalized model of quaternary structure for the KDM5C including JmjN, ARID, PHD1, JmjC and ZF domains bound to DNA, substrate histone peptide and enzymatic cofactors. KDM5C JmjN, ARID, PHD1, JmjC, ZF domains, inter domain region, substrate histone peptide, enzymatic cofactors and DNA are marked with yellow, pink, green, purple, orange, blue, red, orange, red, and gray, respectively.