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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Cell Microbiol. 2016 Jul 26;18(12):1815–1830. doi: 10.1111/cmi.12625

Figure 5. AICAR treatment diminished S. aureus-induced inflammatory mediators in microglia, macrophages and neutrophils.

Figure 5

Cultured BV2 mouse microglia (A), bone marrow derived macrophages (B) and neutrophils (C) were plated in 6 well plate (1× 106 cells/well) (n = 6/condition), and treated with AICAR (1mM) one hour before S. aureus infection (MOI 10:1) for 8 h. Culture supernatant was used to quantify the expression of the indicated cytokines by using ELISA. Each data point represents the mean ± SD and the results are representative of at least two independent experiments. Statistical analysis was performed between SA alone and SA+AICAR. Statistical analysis was performed using one-way ANOVA with Bonferroni’s multiple-comparison test ** p < 0.001, *** P < 0.0001.