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. Author manuscript; available in PMC: 2017 Dec 17.
Published in final edited form as: Neuroscience. 2016 Oct 13;339:491–501. doi: 10.1016/j.neuroscience.2016.10.013

Figure 1.

Figure 1

A. Intracisternal injection of CGRP in upper cervical spinal cord increased nociceptive responses to mechanical stimulation of trigeminal neurons. The median number of nocifensive head withdrawals to the 100 g filament in naïve animals compared to animals basally and at 2 h, 1 day, 2 days, or 3 days post intracisternal injection of saline or CGRP is shown. B. The median number of nocifensive withdrawal responses to the 100 g filament was decreased in a time-dependent manner by inhibiting CGRP or PKA activity. Animals were injected intracisternally with CGRP or co-injected with CGRP and the truncated CGRP receptor antagonist peptide CGRP8-37 (CGRP + 8-37) or the selective PKA inhibitor KT 5720 (CGRP + KT 5720).