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. 2016 Oct 31;7(4):621–639. doi: 10.1007/s13300-016-0208-5

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Pathophysiologic abnormalities targeted by currently available antihyperglycemic medications. DPP4i dipeptidyl peptidase 4 inhibitor, GLP1 RA glucagon-like peptide 1 receptor agonist, HGP hepatic glucose production, MET metformin, SGLT2i sodium glucose cotransporter 2 inhibitor, TZD thiazolidinedione. “From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus”. American Diabetes Association, 2009. Copyright and all rights reserved. Material from this publication has been used with the permission of the American Diabetes Association