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. 2016 Jul 4;4(6):457–465. doi: 10.1007/s40336-016-0197-4

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — uPAR PET imaging of patients with newly diagnosed prostate cancer. Representative transverse CT, PET, and co-registered PET/CT images from the first-ever uPAR PET study in humans. Upper panel shows a primary tumor lesion (blue arrow) with high uptake of ⁶⁴Cu-DOTA-AE105. uPAR immunohistochemistry on surgically removed prostate cancer tissue confirmed general pattern of uPAR expression. Bottom images show a uPAR-positive regional lymph node metastasis (blue arrow) with high ⁶⁴Cu-DOTA-AE105 uptake. The subsequent staging operation and histopathological assessment confirmed prostate adenocarcinoma in three out of six removed lymph nodes.

Reproduced from [44] with permission