Fig. 2.

Structure and function of phosphoinositide (4,5)P₂ 5-phosphatase (OCRL-1). Black boxes Exome structure of the OCRL gene, including the alternatively spliced exon 18a, shaded boxes domains/binding sites of the OCRL-1 protein, dashed boxes functions related to the different domains, text in italics intracellular processes involving OCRL-1. PtdIns Phosphoinositide, PH N-terminal pleckstrin homology domain, 5-phosphatase 5-phosphatase domain, ASH ASPM–SPD2–Hydin domain, RhoGap C-terminal (catalytically non-active) Rho GTPase activating-like domain