Table 1.

Typical age at manifestation of symptoms or complications of Lowe syndrome

Age at onset	Manifestation
Prenatal	Cataract
	Elevated alpha-fetoprotein
Neonatal	Cataract
	Muscle hypotonia
	Absent deep tendon reflexes
	Elevated creatinine kinase/lactate dehydrogenase
	Low-molecular-weight proteinuria
1–3 months	Fanconi syndrome
Infancy	Glaucoma
	Growth retardation
	Developmental delay
Childhood	Behavioral abnormalities
	Corneal scarring, keloids
	Tubulointerstitial fibrosis/glomerulosclerosis
Adolescence	Scoliosis
Adulthood	Arthropathy
	End-stage renal disease
No specific age	Convulsions
	Platelet dysfunction