Table 1.

Amino acid replacements via SHM of CDR AGY Ser codons.

Immunogen	Asn (%)	Gly (%)	Thr (%)	Arg (%)	Others (%)	#CDR AGY SHM
Influenzaa	22c	16c	19c	11	32	142
Influenzab	30c	12	23c	16	19	107
West Nile	20	0	60c	20	0	5
Dengue	14	0	43c	29	14	7
Rhinovirus	7	0	15	26	52	27
Avian Influenza	50c	0	17	33	0	12
Hep. A, B, and C	22c	18	18	20	22	72

^aAntibody sequences from Wrammert et al. (23).

^bAntibody sequences from Li et al. (24).

^cAmino acid replacements that occurred more often than Arg replacements at CDR AGY Ser codons.