Table 2.

Genomic and metabolomics data implicating bile acids in neurodegenerative disorders.

Disease	Approach	Genetic association	References
PD	Meta-analysis of GWAS data from PD and normal patients	HSD3B7 missense SNP in HSD3B7,	Cheng et al., 2003; Song and Lee, 2013
PD	Meta-analysis of PD miRNA GWAS data	SNPs in a miRNA-binding site in the 3' UTR of HSD3B7	Ghanbari et al., 2016
ALS	Peripheral blood cell eQTL of ALS and normal patients	CYP27A1 eQTL	Diekstra et al., 2012
AD	Plasma metabolomic analysis of AD and normal patients	Increased plasma GUDCA levels in patients with mild cognitive impairment or AD	Mapstone et al., 2014