Table 1.

A summary of the benefits and drawbacks of using hiPSC-CMs to study familial cardiomyopathies.

Pros	Cons
Moderate throughput for studying different mutations using CRISPR/Cas9	Lack of neuro-hormonal, endocrine, and paracrine responses
Able to study mutations that would be lethal in vivo	Immaturity of protein expression, ultrastructure, morphology, mechanical properties
Provides insight during development of disease to understand mechanisms
Using isogenic controls allows for rigorous tests of causality and comparisons of mutations