Figure 4.

Relaxation induced by insulin is blocked by iberiotoxin. Response of human chorionic vein rings pre-constricted with U46619 and exposed to 10 nM insulin is showed in presence of 30 nM wortmannin (A), 50 μM genistein (B) or 100 nM iberiotoxin (C). Maximal responses are shown in (D), as a percentage fraction of the initial vessel response to KCl (see Methods). ^*P < 0.05 vs. non-treated (control) vessels. ^**P < 0.01 vs. non-treated (control) vessels. ^†P < 0.05 vs. values in insulin-treated vessels. Values are mean ± S.E.M. (n = 5–10).