Figure 1.

Podocyte number is higher in FSGS mice given enalapril and losartan. p57/PAS double staining. Podocytes were identified by p57 staining (brown, nuclear); PAS was used to identify scarring. Representative pictures are shown from healthy baseline mice (A) and mice with experimental FSGS treated for 25 days with water (C), hydralazine (D), enalapril (E), or losartan (F). (B) Quantitative results show podocyte depletion at day 3, when mice were randomly assigned to treatment groups. Podocyte number remained low at day 28 in the water- and hydralazine-treated groups. Podocyte number was significantly higher in FSGS animals treated with enalapril of losartan compared with FSGS animals treated with water alone or hydralazine. Data are represented as mean±SD.