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. 2016 Mar 28;27(12):3666–3677. doi: 10.1681/ASN.2015101077

Figure 5.

Figure 5.

IL-17F serves a nonredundant function in crescentic GN. (A) Representative FACS plots showing IL-17A and IL-17F expression after PMA/ionomycin stimulation by CD4+ T cells and γδ T cells isolated from kidneys of nephritic IL-17A–deficient mice and nephritic IL-17F–deficient mice pregated for live CD45+ cells on day 8 of NTN. (B) Quantification of renal CD4+ T cells and γδ T cells of nephritic IL-17A–deficient mice (n=6) and nephritic IL-17F–deficient mice (n=6) at day 8 of NTN. (C) Representative photographs of PAS-stained kidney sections from nephritic IL-17A–deficient mice and nephritic IL-17F–deficient mice at day 8 of NTN (original magnification ×400). (D) Quantification of glomerular crescent formation, interstitial area, glomerular sclerosis, BUN levels, and ACR of nephritic IL-17A–deficient mice (n=6) and nephritic IL-17F–deficient mice (n=5) at day 8 of NTN. Symbols represent individual data points with the mean as horizontal line. *P<0.05; **P<0.01; ***P<0.001.