Figure 8.

IL-17F promotes tissue injury by the induction of neutrophil-attracting chemokines. Diagram depicting the present hypothesis of the chain of events leading to the recruitment of tissue-destructive neutrophils by IL-17F. CD4⁺ T cell- and γδ T cell-derived IL-17F induces the expression and production of chemokines CXCL1 and CXCL5, which then attract CXCR2-expressing neutrophils to the inflamed kidney, leading to the destruction of regular kidney tissue and consequent loss of renal function.