Table 2.
Association of baseline characteristics with annual change in residual renal CLurea among 6538 incident patients on hemodialysis
| Variables | Case Mix–Adjusted Model | Fully Adjusted Model | ||
|---|---|---|---|---|
| β (95% CI) | P Value | β (95% CI) | P Value | |
| Baseline renal CLurea per 1.0 ml/min per 1.73 m2 | −0.62 (−0.65 to −0.59) | <0.001 | −0.70 (−0.74 to −0.67) | <0.001 |
| Age, yr | ||||
| <50 | −0.11 (−0.26 to 0.05) | 0.17 | 0.17 (0.01 to 0.32) | 0.04 |
| 50 to <60 | −0.16 (−0.29 to −0.02) | 0.03 | −0.04 (−0.18 to 0.10) | 0.56 |
| 60 to <70 | Reference | Reference | ||
| 70 to <80 | −0.08 (−0.22 to 0.06) | 0.25 | −0.19 (−0.33 to −0.05) | <0.01 |
| ≥80 | −0.29 (−0.46 to −0.11) | 0.001 | −0.48 (−0.66 to −0.30) | <0.001 |
| Men | −0.01 (−0.12 to 0.10) | 0.90 | 0.26 (0.15 to 0.38) | <0.001 |
| Race/ethnicity | ||||
| Non-Hispanic white | Reference | Reference | ||
| Non-Hispanic black | −0.34 (−0.45 to −0.22) | <0.001 | −0.15 (−0.28 to −0.02) | 0.02 |
| Hispanic and other | −0.32 (−0.44 to −0.19) | <0.001 | −0.10 (−0.22 to 0.03) | 0.14 |
| Medicare as primary insurance | −0.03 (−0.13 to 0.07) | 0.61 | −0.04 (−0.14 to 0.05) | 0.39 |
| Central venous catheter use | 0.09 (−0.01 to 0.19) | 0.06 | 0.19 (0.09 to 0.29) | <0.001 |
| Comorbidities | ||||
| Hypertension | −0.03 (−0.13 to 0.07) | 0.53 | −0.01 (−0.11 to 0.09) | 0.86 |
| Diabetes | −0.16 (−0.27 to −0.05) | 0.004 | −0.20 (−0.31 to −0.08) | 0.001 |
| Congestive heart failure | −0.31 (−0.41 to −0.21) | <0.001 | −0.27 (−0.37 to −0.18) | <0.001 |
| Atherosclerotic heart disease | 0.18 (0.03 to 0.34) | 0.02 | 0.19 (0.04 to 0.34) | 0.01 |
| Other cardiovascular disease | 0.01 (−0.13 to 0.16) | 0.87 | −0.02 (−0.16 to 0.12) | 0.77 |
| spKt/V per SD | 0.01 (−0.05 to 0.06) | 0.79 | 0.01 (−0.05 to 0.07) | 0.79 |
| Body mass index per SD | 0.09 (0.04 to 0.15) | 0.001 | 0.08 (0.02 to 0.14) | <0.01 |
| nPCR, g/kg per d | ||||
| <0.8 | 0.27 (0.12 to 0.43) | <0.001 | 0.19 (0.04 to 0.34) | 0.01 |
| 0.8 to <1.0 | 0.04 (−0.09 to 0.18) | 0.54 | −0.01 (−0.14 to 0.12) | 0.87 |
| 1.0 to <1.2 | Reference | Reference | ||
| ≥1.2 | −0.04 (−0.18 to 0.11) | 0.64 | 0.02 (−0.12 to 0.16) | 0.76 |
| Laboratories | ||||
| Hemoglobin per SD | 0.07 (0.02 to 0.12) | <0.01 | 0.05 (−0.01 to 0.10) | 0.09 |
| Albumin, g/dl | ||||
| <3.2 | −0.56 (−0.70 to −0.41) | <0.001 | −0.73 (−0.89 to −0.58) | <0.001 |
| 3.2 to <3.6 | −0.28 (−0.40 to −0.16) | <0.001 | −0.36 (−0.48 to −0.24) | <0.001 |
| 3.6 to <4.0 | Reference | Reference | ||
| ≥4.0 | 0.07 (0.03 to 0.12) | 0.002 | 0.34 (0.20 to 0.48) | <0.001 |
| Creatinine per SD | −0.39 (−0.45 to −0.33) | <0.001 | −0.38 (−0.45 to −0.31) | <0.001 |
| Calcium per SD | 0.07 (0.03 to 0.12) | 0.002 | 0.08 (0.03 to 0.13) | 0.002 |
| Phosphorus per SD | −0.30 (−0.35 to −0.25) | <0.001 | −−0.17 (−0.22 to −0.11) | <0.001 |
| Intact PTH, pg/ml | ||||
| <160 | 0.28 (0.12 to 0.44) | 0.001 | 0.12 (−0.04 to 0.28) | 0.14 |
| 160 to <320 | 0.23 (0.11 to 0.34) | <0.001 | 0.13 (0.01 to 0.24) | 0.03 |
| 320 to <640 | Reference | Reference | ||
| ≥640 | −0.25 (−0.38 to −0.12) | <0.001 | −0.13 (−0.26 to 0.00) | 0.04 |
| Iron saturation per SD | −0.05 (−0.10 to 0.00) | 0.04 | −0.07 (−0.12 to −0.02) | <0.01 |
| Ferritin, ng/ml | ||||
| <200 | −0.09 (−0.23 to 0.04) | 0.18 | −0.11 (−0.24 to 0.03) | 0.12 |
| 200 to <400 | −0.05 (−0.19 to 0.09) | 0.49 | −0.05 (−0.19 to 0.09) | 0.46 |
| 400 to <800 | Reference | Reference | ||
| ≥800 | 0.19 (−0.08 to 0.45) | 0.16 | 0.25 (−0.01 to 0.51) | 0.06 |
| Bicarbonate per SD | 0.01 (−0.04 to 0.06) | 0.60 | −0.13 (−0.18 to −0.08) | <0.001 |
Case mix variables included baseline urine volume, age, sex, race/ethnicity, primary insurance, central venous catheter use, comorbidities, and spKt/V.