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Apoptosis in the forebrain was evaluated by (a) cleaved caspase-3 and (b) cleaved PARP activation in each group after 6 h of sevoflurane exposure. Exposure to sevoflurane for 6 h increased neuronal apoptosis compared to the control group. Coadministration of sugammadex significantly exacerbated neuronal apoptosis induced by sevoflurane exposure. Sugammadex alone did not cause apoptosis (∗ P < 0.05, n = 8 each).
