Table 4.

Gene burden test for the association of the SLC30A8 locus with T2D-related traits.

Trait	Based on all 118 SNPs			Based on 2 coding SNPs			Based on 11 MSA SNPs
	h geff 2	SE	p	h geff 2	SE	p	h geff 2	SE	p
Ever T2D	0.0000	0.0000	1.0000	0.0005	0.0028	0.8498	0.0080	0.0112	0.4774
Incident T2D	0.0000	0.0000	1.0000	0.0010	0.0052	0.8413	0.0192	0.0223	0.3902
Fasting glucose	0.0000	0.0000	1.0000	0.0000	0.0000	1.0000	0.0047	0.0055	0.3946
Fasting insulin	0.0000	0.0000	1.0000	0.0000	0.0000	1.0000	0.0031	0.0043	0.4720
2-hour glucose	0.0093	0.0101	0.3600	0.0006	0.0023	0.8055	0.0039	0.0055	0.4804
2-hour insulin	0.0037	0.0067	0.5791	0.0000	0.0000	1.0000	0.0021	0.0043	0.6288
HOMA-IR	0.0000	0.0000	1.0000	0.0000	0.0000	1.0000	0.0044	0.0051	0.3898
HOMA-β	0.0000	0.0000	1.0000	0.0000	0.0000	1.0000	0.0057	0.0057	0.4102