Figure 2.

Hippocampal slice cultivated on and recorded with a HD-MEA. (A) An HD-MEA chip with a plastic ring and epoxy to encase the bond wires that connect the CMOS chip to the PCB. (B) A brain slice on top of the HD-MEA. (C) Hippocampal slice attached on the electrode array area with chicken plasma and thrombin. Different sub-structures of the hippocampus are labeled, including the cornu ammonis areas (CA3, CA1), and the dentate gyrus (DG). The photo was taken on DIV 0. (D) Amplitude map of the detectable activity from a slice culture. The whole array was scanned to check slice culture activity on DIV 4.