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. 2016 Nov 22;10:516. doi: 10.3389/fnins.2016.00516
B
Phenotype SNP p-value Z Allele Risk Allele
Social communications ABC—Social withdrawal OXTR rs4686302 0.036 –2.09 T C
OXTR rs2268493 0.013 –2.49 C T
ADOS—Social affect OXTR rs2254298 0.023 2.27 A A
Restricted/Repetitive behaviors ABC—Stereotypy OXTR rs4686302 0.018 2.37 C C
ADOS—RRB OXTR rs1042778 0.011 –2.54 T G
ADI—IS OXTR rs2268493 0.039 –2.07 C T

(A) list the SNPs in both OXTR and AVPR1B that were found to be significantly associated with ASD diagnosis. (B) notes the SNP significantly associated with ASD-related phenotypes, mainly social communications and RRBs, in our sample using the additive inheritance model. None of the AVPR1B SNPs were significantly associated with the different subphenotypes (p > 0.100). The remaining OXTR SNPs were also not significantly associated with the subphenotypes (p > 0.054).

*

denotes significant after correcting for multiple comparisons.