B | ||||||
---|---|---|---|---|---|---|
Phenotype | SNP | p-value | Z | Allele | Risk Allele | |
Social communications | ABC—Social withdrawal | OXTR rs4686302 | 0.036 | –2.09 | T | C |
OXTR rs2268493 | 0.013 | –2.49 | C | T | ||
ADOS—Social affect | OXTR rs2254298 | 0.023 | 2.27 | A | A | |
Restricted/Repetitive behaviors | ABC—Stereotypy | OXTR rs4686302 | 0.018 | 2.37 | C | C |
ADOS—RRB | OXTR rs1042778 | 0.011 | –2.54 | T | G | |
ADI—IS | OXTR rs2268493 | 0.039 | –2.07 | C | T |
(A) list the SNPs in both OXTR and AVPR1B that were found to be significantly associated with ASD diagnosis. (B) notes the SNP significantly associated with ASD-related phenotypes, mainly social communications and RRBs, in our sample using the additive inheritance model. None of the AVPR1B SNPs were significantly associated with the different subphenotypes (p > 0.100). The remaining OXTR SNPs were also not significantly associated with the subphenotypes (p > 0.054).
denotes significant after correcting for multiple comparisons.