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Cortico-striatal-thalamo-cortical re-entry circuits including core and shell parts of the nucleus accumbens. The existence of the re-entry circuit including the subgenual cingulate cortex is still hypothetical. LC, locus coeruleus; VTA, ventral tegmental area. Red arrows, glutamatergic; blue arrows, GABAergic; green arrows, adrenergic; gray arrows, dopaminergic.
