TABLE 6.

Pharmacological parameters of results shown in Fig. 6

Top and bottom are expressed as fold of basal, and log EC₅₀ is expressed as logged EC₅₀ (M).

	WT		H17A/H19A
	ZnCl2 (+) (N = 8)	ZnCl2 (−) (N = 8)	ZnCl2 (+) (N = 5)	ZnCl2 (−) (N = 5)
GPR39-C3
Top	30.27 ± 0.57	33.25 ± 2.31	25.87 ± 0.55	29.07 ± 2.02
Bottom	1.09 ± 0.36	1.00 ± 0.16	1.08 ± 0.34	1.00 ± 0.24
Log EC50	−7.99 ± 0.04	−6.22 ± 0.11	−7.76 ± 0.04	−6.43 ± 0.10
Hill slope	1.52 ± 0.17	0.69 ± 0.05	1.51 ± 0.18	0.84 ± 0.10
LY2784544
Top	23.16 ± 0.52	7.10 ± 0.78	19.26 ± 0.56	7.23 ± 0.97
Bottom	0.89 ± 0.25	1.00 ± 0.03	0.91 ± 0.27	1.00 ± 0.06
Log EC50	−8.17 ± 0.04	−5.81 ± 0.11	−8.07 ± 0.04	−5.91 ± 0.12
Hill slope	1.45 ± 0.15	1.27 ± 0.16	1.61 ± 0.23	1.57 ± 0.38
GSK2636771
Top	22.61 ± 0.59	N.D.	22.85 ± 0.93	N.D.
Bottom	0.831 ± 0.21	1.00 ± 0.03	0.91 ± 0.27	1.00 ± 0.07
Log EC50	−7.068 ± 0.04	>−4.00	−6.94 ± 0.06	>−4.00
Hill slope	1.179 ± 0.11	1.59 ± 0.86	1.05 ± 0.13	1.703 ± 0.75

N.D., could not determine; WT, wild type.