TABLE 7.

Pharmacological parameters of results shown in Fig. 7

Top and bottom are expressed as fold of basal, and log EC₅₀ is expressed as logged EC₅₀ (M).

	WT		H17A/H19A
	ZnCl2 (+) (N = 4)	ZnCl2 (−) (N = 4)	ZnCl2 (+) (N = 3)	ZnCl2 (−) (N = 3)
GPR39-C3
Top	3.21 ± 0.08	3.07 ± 0.10	3.72 ± 0.14	3.75 ± 0.22
Bottom	1.18 ± 0.11	1.00 ± 0.10	1.07 ± 0.17	1.03 ± 0.11
Log EC50	−8.48 ± 0.10	−8.00 ± 0.12	−8.30 ± 0.14	−7.17 ± 0.14
Hill slope	1.20 ± 0.30	0.94 ± 0.23	1.01 ± 0.29	0.90 ± 0.23
LY2784544
Top	3.94 ± 0.12	4.41 ± 0.38	3.77 ± 0.13	3.85 ± 0.16
Bottom	1.31 ± 0.22	1.00 ± 0.07	1.09 ± 0.27	1.03 ± 0.04
Log EC50	−8.51 ± 0.16	−6.35 ± 0.14	−8.72 ± 0.18	−6.23 ± 0.07
Hill slope	0.63 ± 0.15	0.94 ± 0.18	0.88 ± 0.29	1.15 ± 0.15
GSK2636771
Top	3.68 ± 0.12	3.68 ± 0.63	3.74 ± 0.12	3.00 ± 0.11
Bottom	1.36 ± 0.12	1.01 ± 0.05	1.14 ± 0.15	1.01 ± 0.02
Log EC50	−7.97 ± 0.13	−5.99 ± 0.25	−8.16 ± 0.13	−5.99 ± 0.05
Hill slope	0.86 ± 0.20	1.01 ± 0.28	0.95 ± 0.24	1.35 ± 0.16

WT, wild type.