Fig. 5.

Effect of picrotoxin (i.t.) on the inhibition of bladder overactivity by S1 or S2 dorsal root (DRT) stimulation at motor threshold (T) intensity. (A) Repeated CMGs were performed during AA infusion with or without S1 or S2 DRT stimulation. Black bars under the pressure trace indicate stimulation duration. Stimulation: 5 Hz, 0.2 millisecond, T = 0.4 V for S1, T = 0.18 V for S2. Infusion rate = 2 ml/min. (B) Normalized bladder capacity measured under different conditions. #Indicates significantly (P < 0.05) different from the prestimulation in the untreated or picrotoxin-treated group (one-way analysis of variance).