. 2016 Dec;359(3):401–410. doi: 10.1124/jpet.116.236158

TABLE 1 .

Cimetidine IC₅₀ values for atenolol and metformin

Experiments were performed in triplicate and repeated two times. Data are presented as mean ± S.D. of all pooled measurements (n = 9).

Inhibitor	Transporter	IC₅₀ (μM)		P Value	Fold Difference
Inhibitor	Transporter	Atenolol	Metformin	P Value	Fold Difference
Cimetidine	hOCT2	9.9 ± 1.1	93.5 ± 1.1	P < 0.001	9.4^a
	hMATE1	6.7 ± 1.2	1.5 ± 1.0	P < 0.01	4.5^b
	hMATE2-K	7.1 ± 1.1	9.7 ± 1.3	P = 0.057	1.4^a
Pyrimethamine	hOCT2	1.8 ± 0.2	22.9 ± 1.9	P < 0.001	12.7^a
	hMATE1	0.18 ± 0.006	0.22 ± 0.01	P < 0.01	1.2^a
	hMATE2-K	1.5 ± 0.07	0.3 ± 0.06	P < 0.001	5.0^b
Carvedilol	hOCT2	7.9 ± 0.6	46.4 ± 0.4	P < 0.001	5.9^a
	hMATE1	146.4 ± 0.9	124.2 ± 4.3	P < 0.001	1.2^b
	hMATE2-K	131.2 ± 4.2	78.6 ± 12.5	P < 0.001	1.7^b

^{^a}

IC₅₀ for metformin/IC₅₀ for atenolol.

^{^b}

IC₅₀ for atenolol/IC₅₀ for metformin.