Skip to main content
. 2016 Nov 22;6:37502. doi: 10.1038/srep37502

Figure 2. Sorbitol induced lysis of Plasmodium falciparum parasites expressing Nanoluciferase (NLuc) following pre-treatment with the 400 MMV Malaria Box compounds.

Figure 2

(A) Inhibition of lysis by MMV Malaria Box compounds was quantified by the activity of NLuc released following sorbitol lysis and was expressed as relative light units (RLU) relative to DMSO control. (B) Counter screen of top 20 NPP inhibitors from the MMV Malaria Box. Inhibition of NLuc was measured by adding the MMV compounds to parasites that had been lysed in water. Two compounds MMV665824 and MMV306025 strongly inhibited NLuc activity. Colours and numbers in (A) correspond to those in (B).