Table 1. EC50 values for inhibition of sorbitol-mediated lysis (NPP activity) and growth of P. falciparum blood stage parasites treated with the compounds indicated.
EC50 for Sorbitol Lysis | EC50 for Parasite Growth | |
---|---|---|
NPPB | 1.23 μM | 62.6 μM |
(1.1–1.4) | (49–80) | |
Furosemide | 11.8 μM | 134 μM |
(10–14) | (120–150) | |
MMV020439 | 222 nM | 329 nM |
(170–280) | (280–390) | |
MMV007571 | 367 nM | 857 nM |
(310–440) | (720–1000) |
The EC50 values (in bold) were calculated from the pooled data from three independent replicates of three technical replicates each. 95% confidence intervals are listed in parenthesis.