Table 3. The change in the EC50 of parasite growth following drug treatment between 3D7 parasites and those expressing yeast DHODH (yDHODH) in the presence of proguanil.
| Control |
+ 1 μM Proguanil |
|||
|---|---|---|---|---|
| 3D7 | yDHODH | 3D7 | yDHODH | |
| ATV | 370 pM (290–480) | >2.5 μM | 33.4 pM (25–45) | 42.3 pM (31–59) |
| DSM-1 | 56.5 nM (46–70) | >2.5 μM | 78.7 nM (62–100) | 1.53 μM (120–210) |
| MMV020439 | 288 nM (230–370) | 2.93 μM (2.2 to 4.0) | 20.2 nM (16–26) | 30.8 nM (23–42) |
| MMV007571 | 1.02 μM (0.84–1.2) | 97.5 μM* (55–230) | 291 nM (240–360) | 436 nM (340–560) |
The EC50 values (in bold) were calculated from the pooled data from three independent replicates of three technical replicates each. 95% confidence intervals are listed in parenthesis. *Denotes value extrapolated from regression where inhibition did not reach 50%.