Table 5. Comparison of the EC50 of parasite growth and IC50 for direct inhibition of in vitro PfDHODH activity.
| EC50 for Parasite Growth Inhibition | IC50 for in vitro DHODH Inhibition | |
|---|---|---|
| ATV | 176 pM (130–230) | >50 μM |
| DSM-1 | 64.8 nM (55–77) | 441 nM (130–1500) |
| MMV020439 | 278 nM (230–340) | >250 μM |
| MMV007571 | 1.04 μM (0.92–1.2) | 158 μM* (54–1200) |
The EC50 values are taken from Table 1, IC50 values were calculated from pooled data from three independent replicates of two technical replicates each. 95% confidence intervals are listed in parenthesis. *Denotes values extrapolated from regression where inhibition did not reach 50%.