Table 7. The fold change in the EC50 of parasite growth following drug treatment of 3D7 parasites in normal and PGIM media, and fold change between 3D7 and yDHODH expressing parasites in normal and PGIM media.
| 3D7 EC50 Fold Decrease with PGIM | EC50 Fold Increase with yDHODH |
||
|---|---|---|---|
| Normal | PGIM | ||
| NPPB | 1.6 (p = 0.0523) | 1.3(p = 0.5614) | 1.3 (p = 0.3463) |
| Furosemide | 3.3 (p = 0.0216) | 1.1 (p = 0.6417) | 1.6 (p = 0.2263) |
| MMV020439 | 5.7 (p = 0.0304) | 52 (p = 0.0023) | 4.3 (p = 0.0851) |
| MMV007571 | 1.5 (p = 0.2425) | 17 (p = 0.001) | 6.9 (p = 0.0321) |
P-values were calculated by two-tailed Student’s t-test with Welch’s correction, numbers in bold signify a p-value < 0.05.