Figure 1. Effects of treatment with CL316,243 on muscular strength in wild type mice.

(A) Mice treated with the β3-AR agonist CL316,243 show an increase in the strength score. The score was calculated as the product of the number of links in the heaviest chain held for the full 3 sec, multiplied by the time (sec) it was held (n = 10 CL316,243-treated mice vs n = 9 vehicle-treated mice, unpaired t-test: t₍₁₇₎ = 5.495, p < 0.0001). (B) Grip test shows an increase in peak force in CL316,243-treated mice compared to vehicle (n = 10/9; unpaired t-test: t₍₁₇₎ = 2.978, p = 0.008). ***p < 0.0001, **p < 0.01.