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. 2016 Nov 2;104(6):1671–1682. doi: 10.3945/ajcn.116.137075

TABLE 4.

Treatment effect: changes in blood lipids in the GTE or placebo groups by TC category at baseline1

TC, mg/dL
<200 (n = 388)2
 200–239 (n = 408)
 ≥240 (n = 140)
Lipid and time point GTE (n = 199) Placebo (n = 189) GTE (n = 200) Placebo (n = 208) GTE (n = 64) Placebo (n = 76) P-interaction3
TC, mg/dL 0.01
 Baseline 180 180 216 218 259 260
 Δ Month 6 0.44 4.18 −9.43 −1.54 −19.88 −9.46
 Δ Month 12 4.65 6.06 −7.75 0.41 −21.57 −7.31
 P4 1.00 <0.0001 0.0004
HDL cholesterol, mg/dL 0.19
 Baseline 65 64 74 72 75 75
 Δ Month 6 0.24 1.70 −2.22 −0.35 −3.09 0.17
 Δ Month 12 1.72 1.27 −1.59 0.41 −1.20 0.89
 P4 1.00 0.083 0.37
LDL cholesterol,5 mg/dL 0.06
 Baseline 98 96 124 125 161 163
 Δ Month 6 −0.40 2.99 −7.82 −0.71 −15.23 −8.93
 Δ Month 12 1.92 4.81 −6.80 0.58 −19.58 −7.20
 P4 0.70 <0.0001 0.006
Triglycerides, mg/dL 0.43
 Baseline 89 99 90 101 116 115
 Δ Month 6 3.14 −2.39 3.07 −2.26 −7.99 −0.86
 Δ Month 12 5.21 0.01 3.10 −3.03 −1.89 −7.89
 P4 0.59 0.36 1.00
TC:HDL-cholesterol ratio 0.90
 Baseline 2.94 2.97 3.09 3.25 3.65 3.76
 Δ Month 6 −0.02 0.005 −0.07 −0.03 −0.16 −0.14
 Δ Month 12 −0.02 0.05 −0.06 −0.06 −0.26 −0.19
 P4 1.00 1.00 1.00
Non-HDL cholesterol, mg/dL 0.05
 Baseline 115 116 142 146 184 185
 Δ Month 6 0.20 2.48 −7.21 −1.18 −16.79 −9.63
 Δ Month 12 2.94 4.79 −6.16 −0.001 −20.37 −8.20
 P4 1.00 0.004 0.01
1

Values are least-squares means, Bonferroni-corrected, and adjusted for age and BMI at baseline. GTE, green tea extract; TC, total cholesterol; Δ, change.

2

n = 198 and 189 in the GTE and placebo groups, respectively, for the 12-mo time point.

3

P values for the interaction between treatment and baseline TC category were derived from a mixed-effects repeated-measures ANOVA with adjustment for age and BMI.

4

P values for the overall change in lipids from baseline to months 6 and 12 between the GTE and placebo groups were derived from a mixed-effects repeated-measures ANOVA with adjustment for age and BMI at baseline within each category of TC.

5

One subject was excluded due to missing values at baseline.