TABLE 5.

Treatment effect: changes in blood lipids by baseline BMI category¹

	BMI, kg/m2
	<25 (n = 520)2		25–29.9 (n = 313)		≥30 (n = 103)
Lipid and time point	GTE (n = 256)	Placebo (n = 264)	GTE (n = 147)	Placebo (n = 166)	GTE (n = 60)	Placebo (n = 43)	P-interaction3
TC, mg/dL							0.28
Baseline	207	209	208	210	199	210
Δ Month 6	−5.46	−0.76	−7.87	0.55	−8.79	−3.11
Δ Month 12	−2.67	1.99	−7.19	1.6	−4.67	−2.39
P4	0.058		0.0006		1.00
HDL cholesterol, mg/dL							0.96
Baseline	75	75	66	64	56	59
Δ Month 6	−1.30	0.57	−1.10	0.55	−1.68	0.50
Δ Month 12	0.39	1.08	−0.97	0.53	−0.23	0.50
P4	0.61		0.76		1.00
LDL cholesterol,5 mg/dL							0.35
Baseline	116	116	120	123	118	126
Δ Month 6	−4.41	−0.60	−6.50	0.26	−9.07	−3.05
Δ Month 12	−3.49	1.05	−6.62	1.74	−6.16	−1.40
P4	0.055		0.0007		1.00
Triglycerides, mg/dL							0.06
Baseline	79	90	108	115	119	127
Δ Month 6	1.25	−3.54	−1.29	0.24	10.09	−2.42
Δ Month 12	2.05	−0.98	2.04	−4.04	11.92	−7.19
P4	1.00		1.00		0.031
TC:HDL-cholesterol ratio							0.65
Baseline	2.87	2.93	3.28	3.52	3.7	3.78
Δ Month 6	−0.04	−0.04	−0.08	−0.01	−0.1	−0.09
Δ Month 12	−0.07	−0.01	−0.07	−0.04	−0.08	−0.15
P4	1.00		1.00		1.00
Non-HDL cholesterol, mg/dL							0.30
Baseline	132	134	142	146	142	151
Δ Month 6	−4.17	−1.33	−6.76	0.01	−7.08	−3.58
Δ Month 12	−3.06	0.89	−6.22	1.07	−4.41	−2.86
P4	0.42		0.0066		1.00

¹Values are least-squares means, Bonferroni-corrected, and adjusted for age and BMI at baseline. GTE, green tea extract; TC, total cholesterol; Δ, change.

²n = 255 and 264 in the GTE and placebo groups, respectively, for the 12-mo time point.

³P values for the interaction between treatment and baseline BMI category were derived from a mixed-effects repeated-measures ANOVA with adjustment for age and BMI.

⁴P values for the overall changes in lipids from baseline to months 6 and 12 between the GTE and placebo groups were derived from a mixed-effects repeated-measures ANOVA with adjustment for age and BMI at baseline within each BMI category.

⁵One subject was excluded due to missing values at baseline.