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. 2016 Oct 12;104(6):1665–1670. doi: 10.3945/ajcn.116.139030

TABLE 2.

Concentrations of plasma metabolites by TCN2 776C→G genotype1

Metabolite Total (n = 171) CC (n = 79) CG (n = 61) GG (n = 31) P
Vitamin B-12,2 pmol/L 366.0 ± 9.8 398.0 ± 30.5 336.5 ± 31.7* 317.0 ± 33.9** <0.01
Homocysteine,3 μmol/L 10.7 ± 1.0 9.9 ± 1.1 10.1 ± 1.1 10.7 ± 1.1 0.61
1

TCN2, transcobalamin gene.

2

All values are means ± SEs. ANCOVA was used to determine the association of the TCN2 polymorphism with the plasma concentration of vitamin B-12. Adjustments were made for sex, age, BMI, education, alcohol intake, race or ethnicity, smoking status, vitamin B-12 intake, and serum creatinine concentration as well as for multiple comparisons. *,**Compared with the CC genotype, *P < 0.02; **P = 0.01.

3

All values are geometric means ± SEs. ANCOVA was used to determine the association of the TCN2 polymorphism with the plasma concentration of homocysteine. Adjustments were made for sex, age, BMI, education, alcohol intake, race or ethnicity, smoking status, vitamin B-12 intake, serum concentrations of creatinine, and plasma concentrations of folate and pyridoxal 5′-phosphate as well as for multiple comparisons.