TABLE 3.
Association between peripheral neuropathy and TCN2 776C→G genotype1
| CC genotype (reference group) |
CG genotype |
GG genotype (variant) |
||||
| Cases/total, n | OR | Cases/total, n | OR (95% CI) | Cases/total, n | OR (95% CI) | |
| Overall | 33/79 | 1 | 25/61 | 1.26 (0.56, 2.81) | 17/31 | 3.33 (1.15, 9.64)* |
| Folate intake,2 μg DFE/d | ||||||
| ≤800 | 24/47 | 1 | 11/26 | 1.11 (0.31, 3.93) | 7/12 | 1.49 (0.18, 12.33) |
| >800 | 9/32 | 1 | 14/35 | 1.30 (0.38, 4.51) | 10/19 | 6.90 (1.31, 36.36)** |
1
Logistic regression analyses were adjusted for sex, age, BMI, education, alcohol intake, serum creatinine concentration, race or ethnicity, smoking status, vitamin B-12 intake, diagnosis of diabetes, and diagnosis of hypertension. *P = 0.03, **P = 0.02. DFE, dietary folate equivalent; TCN2, transcobalamin gene.
2
TCN2 genotype × folate intake, P-interaction = 0.8.