Table 3.
The association between individual benzodiazepine use and dementia based on the Canada Vigilance Adverse Reaction Online Database
| Cases | Non-cases | ROR | 95% CI | IC | 95% CI | |
|---|---|---|---|---|---|---|
| Benzodiazepines | 4,877 | 72,164 | 1.88 | 1.83-1.94 | 0.85 | 0.80-0.89 |
| Short-acting | - | - | - | - | - | - |
| Medium-acting | 3,317 | 54979 | 1.67 | 1.61-1.73 | 0.69 | 0.64-0.74 |
| Lorazepam | 2,818 | 41,481 | 1.88 | 1.81-1.95 | 0.85 | 0.80-0.91 |
| Alprazolam | 404 | 11,810 | 0.94 | 0.85-1.04 | -0.09 | -0.24-0.06 |
| Bromazepam | 95 | 1,688 | 1.54 | 1.26-1.90 | 0.59 | 0.29-0.89 |
| Long-acting | 1,560 | 17,185 | 2.51 | 2.38-2.64 | 1.24 | 1.16-1.32 |
| Diazepam | 1,268 | 14,463 | 2.42 | 2.28-2.56 | 1.19 | 1.11-1.28 |
| Chlordiazepoxide | 256 | 2,360 | 2.98 | 2.62-3.39 | 1.47 | 1.28-1.65 |
| Medazepam | 0 | 10 | 0.00 | - | -0.47 | -3.49-2.54 |
| Clorazepate | 36 | 352 | 2.80 | 1.99-3.95 | 1.33 | 0.84-1.83 |
| Ultra-long-acting | - | - | - | - | - | - |
Cases: number of reports of dementia
Non-cases: all reports of adverse drug reactions other than dementia
ROR: reporting odds ratio
IC: information component
CI: confidence interval