Table 7.

Summary of signal detection for benzodiazepine-associated dementia

	FAERS	Canada	Prescription
Benzodiazepines	↑	↑	↑
Short-acting	↑	-	↑
Etizolam	↑	-	↑
Clotiazepam	↑	-	↑
Flutazolam	nd	-	nd
Medium-acting	↑	↑	↑
Lorazepam	↑	↑	nd
Alprazolam	↑	nd	nd
Fludiazepam	nd	-	nd
Bromazepam	↑	↑	↑
Nimetazepam	nd	-	nd
Long-acting	↑	↑	↑
Diazepam	↑	↑	↑
Cloxazolam	↑	-	↑
Chlordiazepoxide	↑	↑	↑
Medazepam	↑	-	nd
Clorazepate	↑	↑	nd
Ultra-long-acting	↑	-	↑
Flutoprazepam	nd	-	nd
Loflazepate	↑	-	↑
Mexazolam	nd	-	nd
Oxazolam	↑	-	nd
Prazepam	↑	-	-

FAERS: The US Food and Drug Administration (FDA) Adverse Event Reporting System

↑: A positive signal was detected (This means the benzodiazepine anxiolytic drug may be associated with an increased risk of dementia).

nd: A signal was not detected.