Table 2.
Frequently alternated loci and interesting genes in ESCC samples
| Chromosome | Genomic coordinates (NCBI Build 36.3) (bp) |
Frequency | Selected interesting gene (s) | |
|---|---|---|---|---|
| Gains | 1q21.3-qter | 153,250,154-246,756,433 | 8/19 | OBSCN, PTPRC, KCNK2, RGS1, KCNH1, S100A3, ENAH |
| 3q13.11-qter | 104,562,526-199,325,140 | 8/19 | TNK2, TNFSF10, FGF12 | |
| 5pter-p11 | 68,753-45,806,337 | 10/19 | SLC1A3, TRIO, RNASEN,TERT, IRX1, FGF10 | |
| 7pter-p15.3 | 137,567-23,662,661 | 9/19 | TWIST1, MAD1L1, NUDT1 | |
| 7p12.1-p11.2 | 51,937,714-56,087,631 | 9/19 | SEC61G, EGFR, ECOP, PSPH | |
| 7q11-q11.2 | 61,093,897-66,168,768 | 8/19 | ZNF107, ZNF92, GUSB, RABGEF1 | |
| 8p12-qter | 37,175,015-14,6262,725 | 9/19 | MYC, WISP1, FOXH1 | |
| 11q13.2-q13.3 | 68,687,593-70,681,358 | 14/19 | MYEOV, CCND1,ORAOV1, FGF19, FGF4, FGF3, ANO1, FADD, PPFIA1, CTTN, SHANK2 | |
| 12pter-p13.31 | 18,891-8,250,087 | 9/19 | CCND2, FGF23, TNFRSF1A, LTBR, GRIN2B | |
| 17q24.2 | 61,843,907-63,875,054 | 8/19 | BPTF, KPNA2 | |
| 20q11.21-qter | 29,275,015-62,387,649 | 11/19 | E2F1, AURKA | |
| 22q11.21-q11.22 | 18,756,412-21,706,352 | 9/19 | CRKL, UBE2L3, MAPK1, PPM1F | |
| Losses | 3pter-p11.1 | 37,570-90,393,787 | 12/19 | FANCD2, CTNNB1, WNT7A, FBLN2, TGFBR, FHIT |
| 4pter-p12 | 191-48,150,025 | 8/19 | UCHL1 | |
| 4q28.3-q31.22 | 135,093,980-145,125,004 | 8/19 | SETD7 | |
| 4q31.3-q32.1 | 152,306,484-158,362,524 | 8/19 | FBXW7 | |
| 9pter-p12 | 81,476-42,344,999 | 8/19 | MTAP, CDKN2A, CDKN2B, PCSK5 | |
| 11q22.3-qter | 102,643,870-134,450,069 | 9/19 | ATM | |
| 13q12.11-q22.1 | 20,975,030-72,617,826 | 8/19 | CDK8, BRCA2, STARD13, ATP7B |