TABLE 2.
Plasma concentrations of micronutrients at weeks 14 and 30 of pregnancy by supplementation regimen in a selected sample of rural Bangladeshi women participating in the MINIMat trial1
| Maternal micronutrient supplementation |
Maternal food supplementation |
||||||
| Fe30F (n = 213) | Fe60F (n = 216) | MMN (n = 212) | P2 | Early invitation (n = 313) | Usual invitation (n = 328) | P2 | |
| Vitamin B-12 | |||||||
| 14 wk pregnancy,3 pmol/L | 151 (141, 164) | 147 (133, 161) | 150 (138, 162) | 0.84 | 153 (144, 164) | 145 (136, 156) | 0.28 |
| Mean difference4 | Reference | −0.04 (−0.16, 0.08) | −0.02 (−0.14, 0.10) | 0.05 (−0.04, 0.15) | Reference | ||
| 30 wk pregnancy,3 pmol/L | 101 (94, 110) | 110 (101, 120) | 119 (110, 128) | 0.02 | 112 (105, 120) | 108 (100, 114) | 0.36 |
| Mean difference4 | Reference | 0.09 (−0.03, 0.20) | 0.16 (0.04, 0.28)** | 0.04 (−0.05, 0.14) | Reference | ||
| Folate | |||||||
| 14 wk pregnancy,3 nmol/L | 10.4 (9.78, 11.1) | 10.4 (9.68, 11.1) | 10.4 (9.68, 11.1) | 1.00 | 10.7 (10.1, 11.2) | 10.2 (9.68, 10.7) | 0.20 |
| Mean difference4 | Reference | −0.00 (−0.09, 0.09) | −0.00 (−0.09, 0.09) | 0.05 (−0.02, 0.12) | Reference | ||
| 30 wk pregnancy,3 nmol/L | 20.7 (18.9, 22.7) | 21.3 (19.7, 23.1) | 21.8 (20.1, 23.3) | 0.69 | 20.7 (19.3, 22.2) | 21.8 (20.3, 23.1) | 0.37 |
| Mean difference4 | Reference | 0.03 (−0.08, 0.14) | 0.05 (−0.06, 0.16) | −0.04 (−0.13, 0.05) | Reference | ||
| Ferritin | |||||||
| 14 wk pregnancy,3 μg/L | 31.8 (28.8, 35.2) | 34.5 (31.5, 37.7) | 34.5 (31.2, 37.7) | 0.41 | 34.5 (31.8, 37.3) | 32.8 (30.3, 35.12) | 0.37 |
| Mean difference4 | Reference | 0.08 (−0.05, 0.21) | 0.08 (−0.06, 0.21) | 0.05 (−0.06, 0.16) | Reference | ||
| 30 wk pregnancy,3 μg/L | 16.1 (14.4, 17.8) | 14.9 (13.6, 16.4) | 16.1 (14.7, 17.5) | 0.50 | 16.0 (14.4, 17.3) | 15.5 (14.3, 16.8) | 0.58 |
| Mean difference4 | Reference | −0.07 (−0.21, 0.06) | −0.00 (−0.14, 0.14) | 0.03 (−0.08, 0.14) | Reference | ||
| Zinc | |||||||
| 14 wk pregnancy,3 μmol/L | 8.41 (8.08, 8.76) | 8.58 (8.25, 8.94) | 8.58 (8.25, 9.02) | 0.75 | 8.50 (8.25, 8.85) | 8.50 (8.25, 8.85) | 0.96 |
| Mean difference4 | Reference | 0.02 (−0.04, 0.08) | 0.02 (−0.04, 0.08) | −0.00 (−0.05, 0.05) | Reference | ||
| 30 wk pregnancy,3 μmol/L | 7.54 (7.24, 7.92) | 7.61 (7.32, 8.00) | 7.77 (7.54, 8.08) | 0.63 | 7.69 (7.46, 8.00) | 7.61 (7.39, 7.92) | 0.69 |
| Mean difference4 | Reference | 0.01 (−0.05, 0.07) | 0.03 (−0.03, 0.09) | 0.01 (−0.04, 0.06) | Reference | ||
1
**P < 0.01. Fe30F, 30 mg Fe and 400 μg folic acid; Fe60F, 60 mg Fe and 400 μg folic acid; MINIMat, Maternal and Infant Nutrition Intervention, Matlab; MMN, multiple micronutrient supplement.
2
Difference in mean of micronutrients between supplementation regimens, analyzed by ANOVA or t test.
3
Values are geometric means (95% CIs).
4
Values are loge mean differences (95% CIs) with the Fe60F and usual invitation to food supplementation regimen as the references, analyzed by using general linear models.