TABLE 1.
Characteristics of the 2570 adult survivors of childhood cancer in the SJLIFE cohort1
| Value | |
| Age at study, y | 32.3 ± 8.3 |
| Sex, n (%) | |
| Male | 1326 (51.6) |
| Female | 1244 (48.4) |
| Race/ethnicity, n (%) | |
| Non-Hispanic white | 2141 (83.3) |
| Non-Hispanic black | 340 (13.2) |
| Other | 89 (3.5) |
| Education, n (%) | |
| Grades 0–12 | 692 (26.9) |
| Some post–high school | 805 (31.3) |
| College graduate | 923 (35.9) |
| Smoking,2 n (%) | |
| Nonsmoker | 1665 (64.8) |
| Former smoker | 292 (11.4) |
| Current smoker | 585 (22.8) |
| Alcohol consumption, n (%) | |
| Nondrinker | 1188 (46.2) |
| <14 g ethanol/d | 932 (36.3) |
| ≥14 g ethanol/d | 406 (15.8) |
| Physical activity,3 n (%) | |
| Active | 1270 (49.4) |
| Inactive | 1253 (48.8) |
| BMI,4 kg/m2 | 28.5 ± 7.4 |
| Weight status,4 n (%) | |
| Underweight (BMI <18.5) | 89 (3.5) |
| Normal weight (BMI = 18.5–24.9) | 837 (32.6) |
| Overweight (BMI = 25–29.9) | 730 (28.4) |
| Obese (BMI ≥30) | 896 (34.9) |
| Height,5 SDS | −0.25 (1.17) |
| Primary diagnosis, n (%) | |
| Leukemia | 986 (38.4) |
| Lymphoma | 497 (19.4) |
| Embryonal tumor | 335 (13.1) |
| Sarcoma | 328 (12.8) |
| Central nervous system tumor | 239 (9.3) |
| Other | 181 (7.1) |
| Age at diagnosis, y | 8.3 ± 5.6 |
| Time from diagnosis, y | 24.1 ± 8.1 |
| Treatment exposures, n (%) | |
| Radiation (any) | 1532 (59.6) |
| Brain | 916 (35.6) |
| Abdomen | 588 (22.9) |
| Alkylating agents | 1627 (63.3) |
| Anthracyclines | 1499 (58.3) |
| Antimetabolites | 1369 (53.3) |
| Glucocorticoids | 1260 (49.0) |
Values are means ± SDs unless otherwise indicated. MVPA, moderate-to-vigorous physical activity; SDS, SD score; SJLIFE, St. Jude Lifetime.
Smokers were defined as individuals who reported smoking ≥100 cigarettes during their lifetime, with former smokers defined as not currently smoking and current smokers defined as currently smoking.
Minutes per week of MVPA was calculated by summarizing minutes, with vigorous physical activities weighted at 1.67 min for each minute of vigorous physical activity. Participants were classified as physically active if MVPA met or exceeded 150 min/wk, according to the CDC Physical Activity Guidelines for Americans (21).
BMI was calculated by dividing weight in kilograms by height in meters squared, adjusted for amputation status. Participants were classified as underweight (BMI <18.5), normal weight (BMI = 18.5–24.9), overweight (BMI = 25–29.9), or obese (BMI ≥30).
Height was assessed by SDS. Raw height was converted to the SDS by comparing the height of the survivors with the mean height of a reference population (i.e., the 2000 CDC growth chart).