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. 2016 Nov 22;7:446. doi: 10.3389/fphar.2016.00446

FIGURE 4.

FIGURE 4

α5-PAM has no anti-stress properties in male mice even after augmenting UCMS with single housing and increased α5-PAM dose. (A) UCMS combined with isolation housing results in no change in EPM behavior, but a significant decrease in the percentage of distance traveled in the OF, an increase in the latency to bite the pellet in the NSF, and an increase in latency to bite the cookie in the cookie test. No significant effect in any individual test of chronic α5-PAM treatment. (B) No change in stress induced behaviors in the EPM, OFT, NSF, or cookie test following acute or chronic treatment with 37.5 mg/kg α5-PAM. (C) Overall emotionality Z-scores are increased following UCMS-VEH treatment compared to NS-VEH mice. α5-PAM treatment does not remediate the increased emotionality induced by UCMS in male mice. (D) No effect of acute or chronic α5-PAM on stress-induced behaviors in male mice. Data represent mean ± SEM (N = 12 per group). ∗p < 0.05, ∗∗p < 0.01.