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Nanog regulates self-renewal and pluripotency in pluripotent stem cells. Nanog is capable of regulating self-renewal and pluripotency in inner cell mass (ICM)-derived embryonic stem cells (ESCs). Nanog, in combination with Oct4, Sox2 and Lin28, can be utilized to induce efficient reprogramming in fibroblasts to generate induced pluripotent stem cells (iPSCs).
