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Roles of Nanog in Cancer. Collaborating with c-myc, Oct4 and Sox2, Nanog regulates self-renewal, proliferation, epithelial-mesenchymal transition (EMT) and metastasis of cancer cells through miscellaneous pathways. Nanog expression is regulated by c-Jun/β-catenin and can be suppressed by p53. Consistently, miR-21 can activate Nanog pathway by direct inhibition of p53.
