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. 2016 Nov 22;6:37751. doi: 10.1038/srep37751

Figure 6. Silymarin attenuated CSE-stimulated inflammatory cytokine release in an autophagy- and ERK/p38 MAPK-dependent manner.

Figure 6

(A) Beas-2B cells pretreated with silymarin (20 μM), (B) ERK/p38 MAPK inhibitors U0126(10 μM) and SB203580(10 μM), or (C) negative control/Atg5/Beclin-1 siRNA (100 nM) were exposed to 6%CSE for 24 h. The secretion of TNF-α, IL-6 and IL-8 in supernatants were detected by ELISA. Data were averaged from a duplicate of each sample and from three independent experiments. Values are expressed as mean ± SEM (n = 3). *P < 0.05 with respect to the control group; #P < 0.05 with respect to the CSE-exposed group.